Comparison of metoclopramide, prochlorperazine and placebo in prevention of postoperative nausea and vomiting (PONV) following tonsillectomy in young adults.

摘要: Background: Postoperative nausea and vomiting following anaesthesia surgery are common can create considerable problems regarding management of patients outcome the surgical procedure. Methods: This study evaluates compares efficacy safety metochlopramide to that prochlorperazine in prevention postoperative after tonsillectomy young adult patients. 150 patients, either sex, undergoing under same anaesthetic technique were studied a randomized, double blind, placebo controlled manner. Either metoclopramide 0.1-0.2 mg kg -1 , or 5% Dextose normal saline (5% D/N.S) (2ml) as was injected intravenously 10 minutes before induction general anaesthesia. Episodes nausea, retching/ vomiting, adverse events, vital signs, need for rescue antiemetic drug ( –1 IV) recorded until four hours from end Results: The overall frequency PONV 18%, 16%, 24% group A (metoclopramide), B (prochlorperazine) C (placebo) respectively. 2%, 8% 12% Prochloperazine group, control These differences did not reach statistical significance (P>0.05). During period 82%, 84% 76% A, respectively found free no events related test medication noted any patient. Conclusion: It is concluded results occurrence experimental statistically significant. However 0.1 – 0.2 be safely administered Prophylactic till availability more efficacious safe drugs. Keywords: (PONV), metoclopramide, prochlorperazine, tonsillectomy.