Metastamirs: a stepping stone towards improved cancer management.
作者： Nicole M. A. White , Eman Fatoohi , Maged Metias , Klaus Jung , Carsten Stephan
DOI: 10.1038/NRCLINONC.2010.173
关键词:
摘要: MicroRNAs (miRNAs) are non-coding RNAs that regulate protein expression. Aberrant miRNA expression in cancer has been well documented; miRNAs can act as oncogenes or tumor-suppressor genes, depending on the cellular context and target genes they regulate, involved tumor progression metastasis. The potential mechanisms by which aggressiveness include migration, invasion, cell proliferation, epithelial-to-mesenchymal transition, angiogenesis apoptosis. MiRNAs various pathways an elicit more than one biological effect a given cell. Existing data show clinical utility of prognostic predictive markers for aggressive metastatic cancers. stability formalin-fixed, paraffin-embedded tissues body fluids is advantageous biomarker discovery validation. In addition, be extracted from small biopsy specimens, further advantage. Finally, therapeutic agents personalized management.
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