Asthma susceptible genes in Chinese population: A meta-analysis
作者： Xiaobo Li , Yonggang Zhang , Jie Zhang , Yuling Xiao , Jin Huang
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摘要: Published data regarding the associations between genetic variants and asthma risk in Chinese population were inconclusive. The aim of this study was to investigate susceptible genes population. authors conducted 18 meta-analyzes for polymorphisms 13 from eighty-two publications. Seven found being associated with asthma, namely: A Disintegrin Metalloprotease 33 (ADAM33) T1-C/T (odds ratio [OR] = 6.07, 95% confidence interval [CI]: 2.69-13.73), Angiotensin-Converting Enzyme (ACE) D/I (OR 3.85, 95%CI: 2.49-5.94), High-affinity IgE receptor β chain (FceRIβ) -6843G/A 1.49, 1.01-2.22), Interleukin 13(IL-13) -1923C/T 2.99, 2.12-4.24), IL-13 -2044A/G 1.07-2.08), Regulated upon Activation, Normal T cell Expressed Secreted (RANTES) -28C/G 1.64, 1.09-2.46), Tumor Necrosis Factor-α (TNF-α) -308G/A(OR 1.42, 1.09, 1.85). After subgroup analysis by age, ACE D/I, β2-Adrenergic Receptor (β2-AR) -79G/C, TNF-α -308G/A, 4 receptor(IL-4R) -1902G/A significantly children. In addition, FceRIβ -6843G/A, adults. ADAM33, FceRIβ, RANTES, TNF-α, ACE, β2-AR, IL-4R could be proposed as Given limited number studies, more are required validate these associations.
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