Cytoskeletal Regulation by AUTS2 in Neuronal Migration and Neuritogenesis

摘要: Summary Mutations in the Autism susceptibility candidate 2 gene ( AUTS2 ), whose protein is believed to act neuronal cell nuclei, have been associated with multiple psychiatric illnesses, including autism spectrum disorders, intellectual disability, and schizophrenia. Here we show that cytoplasmic involved in the regulation of cytoskeleton neural development. Immunohistochemistry fractionation studies localizes not only but also cytoplasm, growth cones developing brain. activates Rac1 induce lamellipodia downregulates Cdc42 suppress filopodia. Our loss-of-function rescue experiments a AUTS2-Rac1 pathway cortical migration neuritogenesis These findings suggest acts as regulator Rho family GTPases contribute brain development give insight into pathology human disorders mutations.