Synthetic galactomannans with potent anti-HIV activity

摘要: Abstract Ring-opening polymerization of a new 1,6-anhydro disaccharide monomer, 1, 6-anhydro-2, 3- di - O -benzyl-4- -(2′, 3′, 4′, 6′- tetra -benzyl-α- d -galactopyranosyl)-α- -mannopyranose, was carried out using PF 5 as catalyst under high vacuum at −60 °C to give galactose branched mannopyranan (synthetic galactomannan), 4- -α- -galactopyranosyl-(1 → 6)-α- -mannopyranan, after debenzylation with Na in liquid NH 3 . The ring-opening copolymerization 6-anhydro-tri- -mannopyranose various feeds also performed synthetic galactomannans proportions branches. After sulfation, sulfated were found have anti-HIV activity and cytotoxicity low those standard curdlan dextran sulfates, respectively, which are potent polysaccharides cytotoxicity. mechanism used by poly- l -lysine model peptide the HIV surface protein estimated SPR, DSL, zeta potential measurements, revealing electrostatic interaction between negatively charged sulfate groups positively amino groups.