Immunological regulation of synaptic transmission in isolated guinea pig autonomic ganglia.
作者： D Weinreich , B J Undem
DOI: 10.1172/JCI112984
关键词:
摘要: We have attempted to identify a role for mast cells in autonomic ganglia by examining the effects of antigen challenge on cell-associated mediator release and synaptic transmission through superior cervical ganglion isolated from ovalbumin-sensitized guinea pigs. Ovalbumin induced 7.9 ng histamine, 40 pg immunoreactive sulfidopeptide-leukotriene, 140 immunoreactive-PgD2 per ganglion. produced long-lasting potentiation (51 +/- 4%, mean SEM, n = 66) transmission, protracted nature which could not be mimicked exogenous histamine (10(-5) M). Selective H1 antagonists inhibited antigen-induced potentiation, but did reverse it when added any time after exposure. These results indicate that immunologic activation can directly potentiate neurotransmission sympathetic ganglia. Histamine appears involved induction alone cannot account long term this phenomenon.
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