作者: Eric J. Jenkinson , Graham Anderson
DOI: 10.1016/0952-7915(94)90104-X
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摘要: Thymic organ cultures are currently the only system capable of supporting a full programme T-cell development in vitro. Unmanipulated thymus lobes useful for studying some aspects but limited studies on interactions between thymocytes and stromal cells by their cellular heterogeneity. However, techniques have now been developed association defined lymphoid populations culture where optimal conditions interaction maintained. This approach is being applied to study role individual cell types selection T receptor repertoire.