Fetal Liver Organ Cultures as a Tool to Study Selection Processes During B Cell Development

作者: R. Ceredig , A. G. Rolink , F. Melchers , J. Andersson

DOI: 10.1007/978-3-642-60162-0_2

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摘要: Recent studies concerning B cell development in the mouse embryo have indicated that first cells committed to lineage arise para-aortic splanchnopleura at a time prior hematopoietic colonisation of fetal liver [1]. The lymphoid potential such was revealed by vivo transfer experiments, and has recently been confirmed analysis vitro [2]. Whether what way mature progeny progenitors contribute repertoire developing is less clear. This also raises question quantitative qualitative contribution liver-derived pool cells.

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