The function of lung and blood neutrophils in patients with the adult respiratory distress syndrome. Implications for the pathogenesis of lung infections.

摘要: Pulmonary infections are a frequent cause of morbidity and mortality in patients with the adult respiratory distress syndrome (ARDS), but reason is uncertain. Because neutrophils important for lung defense found increased numbers bronchoalveolar lavage fluid ARDS, we compared functional activities obtained from pulmonary artery blood 28 shortly after onset ARDS. The fluids contained 81.3 ± 9.9% neutrophils, which more than 95% were viable by vital dye exclusion, total protein concentrations (98.8 98.5 mg/dl). production superoxide anion hydrogen peroxide was significantly impaired simultaneously tested normal microbicidal activity Staphylococcus aureus impaired. migration alveolar response to variety ...