Localized accumulation of lead within and among bones from lead-dosed goats

摘要: The principal aim of this study was to gain a better understanding where lead (Pb) accumulates and how it is distributed, within the bones dosed goats. Adult goats were periodically with Pb over number years for primary purpose producing blood pools containing endogenously bound Pb, New York State Blood Lead Proficiency Testing Program. Bone samples (e.g., primarily tibia, femur, humerus, radius) collected post-mortem from 11 animals analyzed content by acid digestion electrothermal atomic absorption spectrometry (ETAAS or GFAAS). Average tibia levels found correlate strongly cumulative dose (r2=0.81). However, concentration in different even small area same bone varied tremendously. Blood-rich trabecular (spongy) bone, such as patella calcaneus, much more enriched than cortical (compact) bone. In some animals, markedly higher at proximal distal ends compared mid-shaft. implications these findings regard noninvasive measurement XRF methods are discussed.