Differential effect of self-stimulation on dopamine release and metabolism in the rat medial frontal cortex, nucleus accumbens and striatum studied by in vivo microdialysis.
作者： Daiichiro Nakahara , Kinji Fuchikami , Norio Ozaki , Tuneo Iwasaki , Toshiharu Nagatsu
DOI: 10.1016/0006-8993(92)90813-O
关键词:
摘要: Abstract Changes in the extracellular levels of dopamine (DA) and its metabolites dopaminergic terminal regions, medial frontal cortex (MFC), nucleus accumbens (NAC), striatum (STR), were measured by microdialysis during self-stimulation forebrain bundle (MFB) rats pretreated with DA uptake inhibitor, nomifensine (1 mg/kg, i.p.).Self-stimulation MFB nomifensine-pretreated caused an increase level MFC NAC but not STR. Self-stimulation also increased concentrations main metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) homovanillic (HVA) to a similar extent lesser Thus, there was regional difference neurochemical changes following either or showing larger DA, DOPAC, HVA than Furthermore, these observed on both hemispheres ipsilateral contralateral stimulation. The results indicate that preferentially activates mesocorticolimbic systems, thereby bilateral increases release metabolism being produced their NAC.
elsevier.com
sci-hub.se 参考文章(49)
Hervé Simon, Louis Stinus, Jean Pol Tassin, Solange Lavielle, Gérard Blanc, Anne-Marie Thierry, Jacques Glowinski, Michel Le Moal, Is the dopaminergic mesocorticolimbic system necessary for intracranial self-stimulation? Biochemical and behavioral studies from A10 cell bodies and terminals. Behavioral and Neural Biology. ,vol. 27, pp. 125- 145 ,(1979) , 10.1016/S0163-1047(79)91745-X
HC Fibiger, FG LePiane, A Jakubovic, AG Phillips, The role of dopamine in intracranial self-stimulation of the ventral tegmental area The Journal of Neuroscience. ,vol. 7, pp. 3888- 3896 ,(1987) , 10.1523/JNEUROSCI.07-12-03888.1987
CR Gallistel, Y Gomita, E Yadin, KA Campbell, Forebrain origins and terminations of the medial forebrain bundle metabolically activated by rewarding stimulation or by reward-blocking doses of pimozide. The Journal of Neuroscience. ,vol. 5, pp. 1246- 1261 ,(1985) , 10.1523/JNEUROSCI.05-05-01246.1985
Catherine Bielajew, Peter Shizgal, Behaviorally derived measures of conduction velocity in the substrate for rewarding medial forebrain bundle stimulation Brain Research. ,vol. 237, pp. 107- 119 ,(1982) , 10.1016/0006-8993(82)90560-1
Jeffrey M. Liebman, Susan Gerhardt, James Prowse, Differential effects of d-amphetamine, pipradrol and bupropion on shuttlebox self-stimulation. Pharmacology, Biochemistry and Behavior. ,vol. 16, pp. 791- 794 ,(1982) , 10.1016/0091-3057(82)90236-2
Charles R. Gerfen, William A. Staines, Hans C. Fibiger, Gordon W. Arbuthnott, Crossed connections of the substantia nigra in the rat. The Journal of Comparative Neurology. ,vol. 207, pp. 283- 303 ,(1982) , 10.1002/CNE.902070308
Elefthèrios Miliaressis, Judith Malette, Daniel Coulombe, The effects of pimozide on the reinforcing efficacy of central grey stimulation in the rat Behavioural Brain Research. ,vol. 21, pp. 95- 100 ,(1986) , 10.1016/0166-4328(86)90087-2
C.R. Gallistel, The role of the dopaminergic projections in MFB self-stimulation Behavioural Brain Research. ,vol. 22, pp. 97- 105 ,(1986) , 10.1016/0166-4328(86)90031-8
Dicky van Heuven-Nolsen, Leo van Wolfswinkel, Jan M. van Ree, Dirk H.G. Versteeg, Electrical stimulation of the ventral tegmental area and catecholamine metabolism in discrete regions of the rat brain Brain Research. ,vol. 268, pp. 362- 366 ,(1983) , 10.1016/0006-8993(83)90505-X
Roberto A. Prado-Alcalá, Ernest W. Kent, Larry D. Reid, Intracranial self-stimulation effects along the route of the nigro-striatal bundle Brain Research. ,vol. 84, pp. 531- 540 ,(1975) , 10.1016/0006-8993(75)90770-2