Mitochondrial common deletion is elevated in blood of breast cancer patients mediated by oxidative stress.

摘要: The 4977 bp common deletion is one of the most frequently observed mitochondrial DNA (mtDNA) mutations in human tissues and has been implicated various cancer types. It generally believed that continuous generation intracellular reactive oxygen species (ROS) during oxidative phosphorylation (OXPHOS) a major underlying mechanism for such mtDNA deletions while antioxidant systems, including Manganese superoxide dismutase (MnSOD), mitigating deleterious effects ROS. However, clinical significance this remains to be explored. A comprehensive investigation on occurrence accumulation copy number was carried out breast carcinoma (BC) patients, benign disease (BBD) patients age-matched healthy donors our study. Meanwhile, representative (ROS production, lipid damage) anti-oxidative features (MnSOD expression level variation) blood samples from these groups were also analyzed. We found much more likely detected BC at relatively high levels content lower. This alteration associated with higher MnSOD damages both BBD patients. Our results indicate may serve biomarker cancer.