Anthracyclines as tumor cell differentiating agents: effects on the regulation of erythroid gene expression.

摘要: Tumor cells, and particularly leukemic can be considered as maturation-arrested cells which have escaped some normal control continue to proliferate. This maturation arrest reversed by differentiation agents such antitumor drugs currently used in conventional cytotoxic chemotherapy. In this respect, anthracyclines been shown trigger the of solid tumor but molecular mechanisms lead differentiating phenotype are still poorly understood. Using human multipotent K562 we demonstrated that subtoxic concentrations acla-cinomycin (ACLA) doxorubicin (DOX) preferentially stimulate hemoglobinic pathway (globins heme synthesis) expression mRNAs globins porphobilinogen deaminase (PBGD). However, our results indicate both exert effect along distinct regulatory pathways. Indeed, only ACLA not DOX induces erythropoiet...