Sympathetic Neuron Survival and Proliferation Are Prolonged by Loss of p53 and Neurofibromin

摘要: The proteins encoded by the p53 and Nf1 tumor suppressor genes are involved in cell signaling regulation of proliferation during normal development differentiation, as well progression. To characterize roles these survival embryonic neurons, we have used dissociated cultures sympathetic superior cervical ganglia (SCG) isolated from single compound-mutant mouse embryos. We defined a temporal window for involvement neuron proliferation. Moreover, our results indicate that cooperativity between mutations prolongs SCG increases incidence neural tube defects