Antioxidative capacity of C60 (buckminsterfullerene) and newly synthesized fulleropyrrolidine derivatives encapsulated in liposomes

摘要: C(60) (buckminsterfullerene or fullerene C(60)) has been recognized an efficient free-radical scavenger. Owing to its high antioxidative capacity, and derivatives have a great potential for application in biological systems where prevention of oxidative cell damage is desirable. However, poor solubility native water represents major drawback use systems. In order increase the efficiency delivery fullerenes target tissues it interest enhance their by developing hydrophilic organoderivatives with retained properties, and/or encapsulating biocompatible liposomes. present study, using EPR spin-trapping spin-labelling techniques, we investigated capacity newly synthesized fulleropyrrolidine Q-C(60) [N-methyl-(2-quinolyl)fulleropyrrolidine(60)] I-C(60) [N-methyl-(2-indolyl)fulleropyrrolidine(60)] encapsulated multilamellar phospholipid The removal (*)OH (hydroxyl radical) O2(*-) (superoxide lipid peroxidation should be stressed as most relevant parameters. When these parameters novel organofullerenes were compared performance C(60), showed similar, even better, characteristics. further research required establish toxicity antioxidant efficacy vivo.