Co-delivery of platelet-derived growth factor (PDGF-BB) and bone morphogenic protein (BMP-2) coated onto heparinized titanium for improving osteoblast function and osteointegration.
作者： Sung Eun Kim , Young-Pil Yun , Jae Yong Lee , June-Sung Shim , Kyeongsoon Park
DOI: 10.1002/TERM.1668
关键词:
摘要: The aim of this study was to improve osteoblast function by delivering two growth factors, PDGF-BB and BMP-2, incorporated onto heparinized titanium (Hep-Ti) substrate. To achieve co-delivery the surface anodized Ti immobilized with heparin, then factors were coated Hep-Ti surface. Incorporation evaluated SEM XPS. Incorporated BMP-2 released from substrate in a sustained manner. In vitro studies revealed that osteoblasts grown on PDGF-BB- BMP-2-immobilized increased ALP activity, calcium deposition, osteocalcin osteopontin levels as compared those alone- or alone-immobilized Hep-Ti. These results suggested using will be promising material for enhancement osteointegration. Copyright © 2013 John Wiley & Sons, Ltd.
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