CYP1A2 polymorphism in Chinese patients with acute liver injury induced by Polygonum multiflorum.
作者： K.F. Ma , X.G. Zhang , H.Y. Jia
关键词:
摘要: The objective of this study was to evaluate the genotype and allelic frequencies CYP1A2 in Chinese patients with acute liver injury induced by Polygonum multiflorum. We examined clinical mechanism P. According diagnostic criteria for drug-induced (DILI), 43 cases multiflorum-induced admitted First Affiliated Hospital, Zhejiang University were identified between January 2008 December 2012. An additional control subjects also chosen. Several alleles, including 1C, 1F, 2, 7, 9, 11 amplified from genomic DNA sequenced. used chi-square test determine whether allele polymorphisms are associated frequency 1C 46.5% DILI patients, which significantly different 27.9% observed healthy subjects. 1F 63.9% compared 57.0% controls; difference not significant. too low be detected. mutation differed that people, indicating is probably related metabolism multiflorum, followed injury.
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R. Deng, T. Yang, Y. Wang, N. Tang, CYP2E1 RsaI/PstI polymorphism and risk of anti-tuberculosis drug-induced liver injury: a meta-analysis. International Journal of Tuberculosis and Lung Disease. ,vol. 16, pp. 1574- 1581 ,(2012) , 10.5588/IJTLD.12.0304
Guillermo Gervasini, Montserrat Garcia, Rosa María Macias, Juan Jose Cubero, Francisco Caravaca, Julio Benitez, Impact of genetic polymorphisms on tacrolimus pharmacokinetics and the clinical outcome of renal transplantation. Transplant International. ,vol. 25, pp. 471- 480 ,(2012) , 10.1111/J.1432-2277.2012.01446.X
Renato Polimanti, Sara Piacentini, Dario Manfellotto, Maria Fuciarelli, Human genetic variation of CYP450 superfamily: analysis of functional diversity in worldwide populations. Pharmacogenomics. ,vol. 13, pp. 1951- 1960 ,(2012) , 10.2217/PGS.12.163
Akiko Soyama, Yoshiro Saito, Nobumitsu Hanioka, Keiko Maekawa, Kazuo Komamura, Shiro Kamakura, Masafumi Kitakaze, Hitonobu Tomoike, Kazuyuki Ueno, Yu-ichi Goto, Hideo Kimura, Masaaki Katoh, Kenji Sugai, Osamu Saitoh, Mitsuru Kawai, Teiichi Ohnuma, Taisuke Ohtsuki, Chieko Suzuki, Narihiro Minami, Naoyuki Kamatani, Shogo Ozawa, Jun-ichi Sawada, Single Nucleotide Polymorphisms and Haplotypes of CYP1A2 in a Japanese Population Drug Metabolism and Pharmacokinetics. ,vol. 20, pp. 24- 33 ,(2005) , 10.2133/DMPK.20.24
Andr??s C??rdenas, Juan Carlos Restrepo, Fernando Sierra, Gonzalo Correa, Acute hepatitis due to shen-min: a herbal product derived from Polygonum multiflorum. Journal of Clinical Gastroenterology. ,vol. 40, pp. 629- 632 ,(2006) , 10.1097/00004836-200608000-00014
Kyoung Ah Jung, Hyun Ju Min, Seung Suk Yoo, Hong Jun Kim, Su Nyoung Choi, Chang Yoon Ha, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung, Ok Jae Lee, Jong Sil Lee, Sang Goon Shim, Drug-Induced Liver Injury: Twenty Five Cases of Acute Hepatitis Following Ingestion of Polygonum multiflorum Thunb. Gut and Liver. ,vol. 5, pp. 493- 499 ,(2011) , 10.5009/GNL.2011.5.4.493
Chi-Chun Wong, Hua-Bin Li, Ka-Wing Cheng, Feng Chen, A systematic survey of antioxidant activity of 30 Chinese medicinal plants using the ferric reducing antioxidant power assay Food Chemistry. ,vol. 97, pp. 705- 711 ,(2006) , 10.1016/J.FOODCHEM.2005.05.049
Gabriela Mazzanti, Lucia Battinelli, Claudia Daniele, Claudio Maria Mastroianni, Miriam Lichtner, Simona Coletta, Sergio Costantini, New Case of Acute Hepatitis Following the Consumption of Shou Wu Pian, a Chinese Herbal Product Derived from Polygonum multiflorum Annals of Internal Medicine. ,vol. 140, pp. W- 30 ,(2004) , 10.7326/0003-4819-140-7-200404060-00042-W3
Philip E. Empey, Genetic predisposition to adverse drug reactions in the intensive care unit. Critical Care Medicine. ,vol. 38, ,(2010) , 10.1097/CCM.0B013E3181DE09F8
RC Zhang, Effects of extract of Polygonum multiflorum on cell cycle arrest and apoptosis of human liver cell line L02 Journal of Chinese Integrative Medicine. ,vol. 8, pp. 554- 561 ,(2010) , 10.3736/JCIM20100608