Hepatotoxicity in Rats Induced by Aqueous Extract of Polygoni Multiflori Radix, Root of Polygonum multiflorum Related to the Activity Inhibition of CYP1A2 or CYP2E1
作者： Deng-Ke Li , Jing Chen , Zhen-Zhen Ge , Zhen-Xiao Sun
DOI: 10.1155/2017/9456785
关键词:
摘要: The objective of this study is to investigate the relationship between hepatotoxicity induced by Polygoni Multiflori Radix (PMR, root Polygonum multiflorum Thunb., He Shou Wu) and activity CYP1A2 or CYP2E1 in rat liver. Levels serum transaminases ALT AST were not altered but liver was significantly inhibited after oral administration aqueous extract PMR under experimental dosage. However, levels increased decreased injection specific inhibitor for combined with PMR, especially repeated treatment over interval times. Liver histopathological observation showed that a moderate injury occurred rats receiving inhibited, there no significant damage CYP alone. These suggested low level from genetic polymorphism among people might be one important reasons clinical practice.
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