Regulation of interkinetic nuclear migration by cell cycle‐coupled active and passive mechanisms in the developing brain

摘要: A hallmark of neurogenesis in the vertebrate brain is apical–basal nuclear oscillation polarized neural progenitor cells. Known as interkinetic migration (INM), these movements are synchronized with cell cycle such that nuclei move basally during G1-phase and apically G2-phase. However, it unknown how direction movement tightly coupled. Here, we show INM proceeds through cycle-dependent linkage cell-autonomous non-autonomous mechanisms. During S to G2 progression, microtubule-associated protein Tpx2 redistributes from nucleus apical process, promotes G2-phase by altering microtubule organization. Thus, links cell-cycle progression autonomous migration. In contrast, vivo observations implanted microbeads, acute S-phase arrest surrounding cells computational modelling suggest basal depends on a displacement effect migrating apically. Our model for explains dynamics progenitors harmonize their extensive proliferation epithelial architecture developing brain.