cAMP-Dependent protein kinase (PKA) subunit mRNA levels in postmortem brain from patients with bipolar affective disorder (BD).

摘要: Earlier findings of elevated basal and stimulated PKA activities, increased immunoreactive levels regulatory catalytic subunits in discrete postmortem brain regions from bipolar disorder (BD) patients suggest that disturbances are involved the pathophysiology BD. subunit mRNA were measured using SYBR Green real-time RT-PCR to determine if previously observed differences RIIbeta Calpha associated with corresponding changes temporal frontal cortices same BD matched controls. In distinct contrast higher immunolabeling reported brain, there no significant compared These infer activity found selected cerebral cortical due a posttranscriptional mechanism, rather than regulation gene transcription and/or stability subunits.