Meta-Analysis of Genome-Wide Linkage Studies of Quantitative Lipid Traits in Families Ascertained for Type 2 Diabetes
作者： Alka Malhotra , Steven C Elbein , Maggie CY Ng , Ravindranath Duggirala , Rector Arya
DOI: 10.2337/DB06-1057
关键词:
摘要: Dyslipidemia is a major risk factor for coronary heart disease, which the predominant cause of mortality in individuals with type 2 diabetes. To date, nine linkage studies quantitative lipid traits have been performed families ascertained diabetes, individually yielding results that were largely nonoverlapping. Discrepancies findings are not uncommon and typically due to limited sample size heterogeneity. address these issues increase power detect linkage, we meta-analysis all published genome scans conducted Statistically significant evidence (i.e., P < 0.00043) was observed total cholesterol on 7q32.3-q36.3 (152.43-182 cM; = 0.00004), 19p13.3-p12 (6.57-38.05 0.00026), 19p12-q13.13 (38.05-69.53 0.00001), 19q13.13-q13.43 (69.53-101.1 0.00033), as well LDL (P 0.00041). Suggestive 0.00860) also 19p12-q13.13, triglycerides 7p11-q21.11 (63.72-93.29 cM), triglyceride/HDL LDL/HDL 16q11.2-q24.3 (65.2-130.4 cM) 19p12-q13.13. Linkage has previously both chromosomes 7 19 several unrelated and, together this meta-analysis, provide compelling regions harbor important determinants levels
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