Premenopausal and postmenopausal differences in bone microstructure and mechanical competence in Chinese‐American and white women

摘要: Compared to white women, premenopausal Chinese-American women have more plate-like trabecular (Tb) bone. It is unclear whether these findings are relevant postmenopausal and if there racial differences in the deterioration of bone microarchitecture with aging. We applied individual trabecula segmentation finite element analysis high-resolution peripheral quantitative computed tomography images quantify within-race age-related Tb plate-versus-rod stiffness. Race–menopause status interactions were assessed. Comparisons between races within menopause adjusted for age, height weight. Adjusted analyses at radius indicated that Chinese-Americans had a higher plate volume fraction (pBV/TV), plate-to-rod ratio (P-R ratio), greater plate-plate junction densities (P-P Junc.D) versus (all p < 0.01), resulting 27% stiffness (p < 0.05). Greater cortical thickness density (Ct.Th Dcort) plates led 19% whole Postmenopausal similar pBV/TV P-P Junc.D, yet P-R women. Ct.Th, Dcort, relatively intact plates, but 12% In both races, Ct.Th Dcort lower no races. parameters also pBV/TV, ratio, Junc D (p < 0.05) There advantages Within-race cross-sectional suggest loss aging Chinese-Americans, though thicker cortices persists.