The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesis.

摘要: The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway mediates diverse and important physiological cell functions which include proliferation, differentiation, survival, motility, autophagy, metabolism. However, dysregulated PI3K/Akt/mTOR has been documented in a wide range neoplasias, including malignant hematological disorders. It is now emerging that this network plays key role during normal hematopoiesis, tightly regulated process resulting the formation all blood lineages. Blood development encompasses complex series events are mainly by actions cytokines, family extracellular ligands stimulate many biological responses array types. Hematopoiesis strictly dependent on correct function bone marrow microenvironment (BMM), as BMM cells secrete most cytokines. Several these cytokines activate regulate differentiation hematopoiesis. Here, we review evidence links signals emanating from cascade with hematopoietic stem myelopoiesis, lineage commitment. We then highlight played aberrant leukemogenesis.