Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study.

摘要: Summary Background Seafood is the predominant source of omega-3 fatty acids, which are essential for optimum neural development. However, in USA, women advised to limit their seafood intake during pregnancy 340 g per week. We used Avon Longitudinal Study Parents and Children (ALSPAC) assess possible benefits hazards a child's development different levels maternal pregnancy. Methods 11 875 pregnant completed food frequency questionnaire assessing consumption at 32 weeks' gestation. Multivariable logistic regression models including 28 potential confounders social disadvantage, perinatal, dietary items were compare developmental, behavioural, cognitive outcomes children from age 6 months 8 years consuming none, some (1–340 week), >340 Findings After adjustment, less than week was associated with increased risk being lowest quartile verbal intelligence quotient (IQ) (no consumption, odds ratio [OR] 1·48, 95% CI 1·16–1·90; some, 1·09, 0·92–1·29; overall trend, p=0·004), compared mothers who consumed more Low also suboptimum prosocial behaviour, fine motor, communication, scores. For each outcome measure, lower pregnancy, higher developmental outcome. Interpretation Maternal did not protect adverse outcomes; rather, we recorded beneficial effects on child intakes week, suggesting that advice could actually be detrimental. These results show risks loss nutrients greater harm exposure trace contaminants eaten weekly.