BMP signaling regulates the tempo of adult hippocampal progenitor maturation at multiple stages of the lineage.

摘要: Novel environmental stimuli, such as running and learning, increase proliferation of adult hippocampal neural stem cells (NSCs) enlarge the population new neurons. However, it remains unclear how increased numbers neurons can be generated in a time frame far shorter than required for proliferating to generate these Here, we show that bone morphogenetic protein (BMP) signaling subgranular zone regulates tempo progenitor cell (NPC) maturation by directing their transition between states quiescence activation at multiple stages along lineage. Virally mediated overexpression BMP4 caused NPC cycle exit slowed normal NPCs, resulting long-term reduction neurogenesis. Conversely, BMP inhibitor noggin promoted entry accelerated maturation. Similarly, receptor type 2 (BMPRII) ablation Ascl1+ intermediate NPCs into Importantly, BMPRII GFAP+ without depleting NSC pool, indicating an rate neurogenesis does not necessarily diminish population. Thus, inhibition is mechanism rapidly expanding pool hippocampus tipping balance quiescence/activation accelerating which they mature Stem Cells 2014;32:2201–2214