Chorioamnionitis and pregnancy outcome in HIV-infected african women

摘要: A cohort study conducted in Kigali Rwanda 1992-93 investigated the effect of chorioamnionitis (CAM) on pregnancy outcomes HIV-positive pregnant women after controlling for common STDs. All attending prenatal clinic at Centre Hospitalier de 24-28 weeks gestation were offered voluntary HIV testing and STD screening. total 286 275 HIV-negative enrolled received monthly clinical follow-up with treatment STDs conditions such as anemia when needed. At enrollment two groups did not differ terms prevalence. On basis histologic examination placenta CAM was diagnosed 27 (9.8%) 28 (9.8%). Independent status there no significant associations between age parity hepatitis B CD4 lymphocyte count. Among significantly associated prematurity (relative risk (RR) 3.0; 95% confidence interval (CI) 1.5-6.3) stillbirth (RR. 4.2; CI 1.6-11.0) premature rupture membranes (RR 2.9; 1.4-6.1). only adverse outcome early neonatal mortality 2.0; 1.6-11.0). The unexpectedly low rate recorded this is probably a result other medical services to participants. This turn suggests that control during may represent feasible intervention reducing vertical transmission developing countries. Further microbiologic studies are recommended elucidate physiopathology HIV-infected pregnancy.