Placental inflammation and perinatal transmission of HIV-1.
作者： Fabian Mwanyumba , Philippe Gaillard , Ingrid Inion , Chris Verhofstede , Patricia Claeys
DOI: 10.1097/00126334-200203010-00006
关键词: Odds ratio 、 Population 、 Chorioamnionitis 、 Viral load 、 Fetus 、 In utero 、 Obstetrics 、 Peripartum Period 、 Medicine 、 Pregnancy 、 Immunology
摘要: The effect of placental membrane inflammation on mother-to-child transmission (MTCT) HIV-1 is reported. Placentas from HIV-1-infected women were examined as part a perinatal project in Mombasa, Kenya. Polymerase chain reaction analysis was used to test for the infants at birth and 6 weeks. maternal seroprevalence 13.3% (298 2,235). overall rate MTCT 25.4%; polymerase revealed that 201 6.0% (12) already HIV-1-positive (intrauterine transmission) 19.4% (39) infected during peripartum period or early neonatal life (perinatal transmission). prevalence acute chorioamnionitis 8.8%, deciduitis 10.8%, villitis 1.6%. Acute independently associated with but not utero (17.9% vs. 6.7%, respectively; adjusted odds ratio, 3.9; 95% confidence interval, 1.2-12.5; p =.025). Other correlates presence HIV genital tract baby's oral cavity high viral load peripheral blood. population attributable fraction 12.8% (95% 1.5%-22.8%) indicated approximately 3% could be prevented if eliminated. We suggest further research role antimicrobial treatment prevention reduction needs performed.
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