The anticonvulant effect of cooling in comparison to α-lipoic acid: a neurochemical study.
作者： Yasser A. Khadrawy , Heba S. AboulEzz , Nawal A. Ahmed , Haitham S. Mohammed
DOI: 10.1007/S11064-013-0995-2
关键词:
摘要: Brain cooling has pronounced effects on seizures and epileptic activity. The aim of the present study is to evaluate anticonvulsant effect brain oxidative stress changes in Na+, K+-ATPase acetylcholinesterase (AchE) activities during status epilepticus induced by pilocarpine hippocampus adult male rat comparison with α-lipoic acid. Rats were divided into four groups: control, rats treated for induction epilepticus, 3 consecutive days acid before subjected whole body 30 min pilocarpine. findings indicated that pilocarine-induced was accompanied a state as clear from significant increase lipid peroxidation (MDA) superoxide dismutase (SOD) decrease reduced glutathione nitric oxide (NO) levels catalase, AchE K+-ATPase. Pretreatment ameliorated restored nearly control However, activity showed decrease. exposed revealed increases MDA NO SOD returned value while persisted. data suggest may have an which be mediated elevated level. drastic unwanted insults such
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