Effect of hypothermia on brain cell membrane function and energy metabolism in experimental Escherichia coli meningitis in the newborn piglet.

摘要: We evaluated the anti-inflammatory and neuroprotective effects of hypothermia during early phase experimental Escherichia coli meningitis in newborn piglet. Hypothermia significantly attenuated meningitis-induced acute inflammatory responses such as increased intracranial pressure, decreased glucose level, lactate concentration, tumor necrosis factor-α level leukocytosis cerebrospinal fluid. Decreased cerebral cortical cell membrane Na+,K+-ATPase activity lipid peroxidation products, indicative brain damage, were improved with hypothermia. also reduction ATP phosphocreatine levels. In summary, ensuing injury neonatal bacterial meningitis.