A strong correlation between glomerular filtration rate and filtration surface in diabetic nephropathy.
作者： H. H. Parving , E. Hommel , G. Nyberg , H. E. Jørgensen , H. Løkkegaard
DOI: 10.1007/BF00277406
关键词:
摘要: Quantitative structural studies were performed in kidney biopsy specimens from 24 long-term Type 1 (insulin-dependent) diabetic patients with persistent albuminuria due to glomerulopathy. Ten receiving antihypertensive treatment, and among the remaining mean blood pressure was 142/91 mmHg (SD = 11/9). The urinary albumin excretion rate showed a range 100 5494 μg/min (geometric 688 μg/min.) Glomerular filtration also wide range, supranormal markedly decreased values (128 28 ml·min−1· (1.73 m2)−1, 75). surface (interface between capillary space) per total number of nephrons (open+occluded) estimated by combined light- electron microscopy. percentage occluded glomeruli as well quantities open taken into account this estimate. A highly significant correlation seen glomerular nephron (r=0.77, p<10−4). contributed significantly variation (for relationship tested separately r=-0.78, p<10−5). volume even larger than that early hypertrophy tended increase closure, indicating compensatory might have place. In constituted smaller percent (the part facing mesangial regions) control subjects.
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