Morphologic Responses to a Murine Erythroblastosis Virus

摘要: A recently described mouse erythroblastosis virus (MEV) was passed to newborn W/Fu rats. The rats developed generalized malignant lymphomas after 6-7 months. Two separate serial cell-free passage series were initiated. Rat induced in less than 20% of the that died within 4 weeks inoculation. surviving remained apparently healthy for months until they from lymphomas. Inoculation C3Hf/Gs mice with same Filtrates caused only 35-50% 3-8 morphologically indistinguishable thymic and by Gross' leukemia virus. different morphologic response observed passages spleen filtrates or plasma erythroblastosis. All In addition, multiple sarcomas polyostotic osteolytic lesions found most such passages. rat but no mice. Erythroblastosis similar disease previously mice, except a marked normoblastosis cerebral hemorrhages which did not occur erythroblastotic arose sites histologically undifferentiated. likewise multicentric origin, affecting particularly vertebrae long bones. Their exact nature could be determined.