The effect of intestinal esterase inhibition on the in vivo absorption and toxicity of di-N-butyl phthalate
作者： R.D. White , D.L. Earnest , D.E. Carter
DOI: 10.1016/0278-6915(83)90276-4
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摘要: Abstract Inhibition of intestinal mucosal esterases by S , -tributylphosphorotrithioate (DEF) did not alter the gastro-intestinal absorption di- n -butyl phthalate (DBP) in rat. After intragastric administration [ 14 C]DBP to control and esterase-inhibited animals, disappearance C from small intestine levels blood were significantly different two groups over first 4 hr. Peak occurred 2 hr after dosing both rats. The circulating C]butyl diester form accounted for less than 5% total at hr, regardless esterase activity. remaining was associated with mono- or more polar metabolites. These data suggest an important role pancreatic esterases, which may be protected DEF-mediated inhibition dtorage zymogen granules, metabolism DBP.
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