Propagation, expansion, and multilineage differentiation of human somatic stem cells from dermal progenitors
作者： Georg Bartsch , James J. Yoo , Paolo De Coppi , M. Minhaj Siddiqui , Gunter Schuch
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摘要: We isolated multipotential mesenchymal stem cells (MSC) from human postnatal dermal tissues. The were expanded and maintained for over 100 population doublings with retention of their chromosomal complement potential multilineage differentiation. Progeny cell lines established a single MSC could be differentiated into adipogenic, osteogenic, myogenic lineages, consistent the conclusion that we clonal, multipotential, somatic line. This study is first to show growth can used engineering tissues in vivo. Clonal MSCs presents profound implications our understanding differentiation development, should provide valuable resource tissue repair.
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