Circadian Clock Control of Nox4 and Reactive Oxygen Species in the Vasculature

摘要: Recent studies have shown that circadian clock disruption is associated with pathological remodeling in the arterial structure and vascular stiffness. Moreover, chronic dysfunction endothelial responses signaling. Reactive oxygen species emerged as key regulators pathology. Previously, we demonstrated exacerbates superoxide production through eNOS uncoupling. To date, impact of mutation on NADPH oxidase expression function not known. The goal current study was to determine if controls Nox4 hydrogen peroxide formation arteries, particularly smooth muscle cells. In aorta, there an increase mice a dysfunctional rhythm (Bmal1-KO mice). addition, gene promoter activated by core transcription factors. Lastly, synchronized cultured human cells, exhibited rhythmic oscillations. These data reveal plays important role control leads subsequent reaction species.