WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells
作者： Elin J Ekström , Caroline Bergenfelz , Verena von Bülow , Filiz Serifler , Eric Carlemalm
关键词:
摘要: Wnt proteins are important for developmental processes and certain diseases. WNT5A is a non-canonical protein that previously has been shown to play role in the progression of malignant melanoma. High expression melanoma tumors correlates formation distant metastasis poor prognosis. This partly described by findings cell lines increases migration invasion.
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Taoyong Chen, Jun Guo, Mingjin Yang, Xuhui Zhu, Xuetao Cao, Chemokine-Containing Exosomes Are Released from Heat-Stressed Tumor Cells via Lipid Raft-Dependent Pathway and Act as Efficient Tumor Vaccine Journal of Immunology. ,vol. 186, pp. 2219- 2228 ,(2011) , 10.4049/JIMMUNOL.1002991
Yana Ren, Jie Yang, Rufeng Xie, Li Gao, Yiming Yang, Huahua Fan, Kaicheng Qian, Exosomal-like vesicles with immune-modulatory features are present in human plasma and can induce CD4+ T-cell apoptosis in vitro. Transfusion. ,vol. 51, pp. 1002- 1011 ,(2011) , 10.1111/J.1537-2995.2010.02909.X
Véronique Proux-Gillardeaux, Rachel Rudge, Thierry Galli, The Tetanus Neurotoxin‐Sensitive and Insensitive Routes to and from the Plasma Membrane: Fast and Slow Pathways? Traffic. ,vol. 6, pp. 366- 373 ,(2005) , 10.1111/J.1600-0854.2005.00288.X
Shaohua Yu, Cunren Liu, Kaihong Su, Jianhua Wang, Yuelong Liu, Liming Zhang, Chuanyu Li, Yingzi Cong, Robert Kimberly, William E. Grizzle, Carla Falkson, Huang-Ge Zhang, Tumor Exosomes Inhibit Differentiation of Bone Marrow Dendritic Cells Journal of Immunology. ,vol. 178, pp. 6867- 6875 ,(2007) , 10.4049/JIMMUNOL.178.11.6867
Manxiang Li, Zongfang Li, Xiuzhen Sun, Statins suppress MMP2 secretion via inactivation of RhoA/ROCK pathway in pulmonary vascular smooth muscles cells. European Journal of Pharmacology. ,vol. 591, pp. 219- 223 ,(2008) , 10.1016/J.EJPHAR.2008.06.082
Karni Schlessinger, Edward J. McManus, Alan Hall, Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity. Journal of Cell Biology. ,vol. 178, pp. 355- 361 ,(2007) , 10.1083/JCB.200701083
Philip D. Da Forno, J. Howard Pringle, Peter Hutchinson, Joy Osborn, Qiang Huang, Linda Potter, Rachael A. Hancox, Alan Fletcher, Gerald S. Saldanha, WNT5A Expression Increases during Melanoma Progression and Correlates with Outcome Clinical Cancer Research. ,vol. 14, pp. 5825- 5832 ,(2008) , 10.1158/1078-0432.CCR-07-5104
Angélique Bobrie, Marina Colombo, Graça Raposo, Clotilde Théry, Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses Traffic. ,vol. 12, pp. 1659- 1668 ,(2011) , 10.1111/J.1600-0854.2011.01225.X
Helmut Erhard, Frank J. R. Rietveld, Margarethe C. van Altena, Eva-B. Br??cker, Dirk J. Ruiter, Robert M.W. de Waal, Transition of horizontal to vertical growth phase melanoma is accompanied by induction of vascular endothelial growth factor expression and angiogenesis Melanoma Research. ,vol. 7, pp. 19- 26 ,(1997) , 10.1097/00008390-199708001-00005
Ralph J. Abi-Habib, Jeffrey O. Urieto, Shihui Liu, Stephen H. Leppla, Nicholas S. Duesbery, Arthur E. Frankel, BRAF status and mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 activity indicate sensitivity of melanoma cells to anthrax lethal toxin Molecular Cancer Therapeutics. ,vol. 4, pp. 1303- 1310 ,(2005) , 10.1158/1535-7163.MCT-05-0145