Combining Electrostatic, Hindrance and Diffusive Effects for Predicting Particle Transport and Separation Efficiency in Deterministic Lateral Displacement Microfluidic Devices.

摘要: Microfluidic separators based on Deterministic Lateral Displacement (DLD) constitute a promising technique for the label-free detection and separation of mesoscopic objects biological interest, ranging from cells to exosomes. Owing simultaneous presence different forces contributing particle motion, feasible theoretical approach interpreting anticipating performance DLD devices is yet be developed. By combining results recent study electrostatic effects in with an advection–diffusion model previously developed by our group, we here propose fully predictive (i.e., ideally devoid adjustable parameters) that includes main physically relevant governing transport one hand, amenable numerical treatment at affordable computational expenses other. The proposed, ensemble statistics stochastic trajectories, validated comparing/contrasting predictions available experimental data encompassing dimensions. comparison suggests low/moderate values flowrate can yield accurate prediction performance, thus making it tool designing device geometries operating conditions nanoscale applications technique.