Pathogenesis of insulin-dependent diabetes mellitus

摘要: Insulin-dependent diabetes mellitus is strongly associated with certain HLA types and the presence of islet cell-specific autoantibodies. The pathogenesis a specific loss pancreatic beta cells. dissection IDDM genes complicated by low recurrence rate disease among first-degree relatives. HLA-DQ2 8 are closest to marked synergistic effect DQ2/8 heterozygotes. associations other often explained linkage disequilibrium. Genetic factors on chromosomes which influence still be fully identified but candidates 11 (insulin gene polymorphisms) 7 (TCR polymorphisms). autoreactivity against GAD65 isoform pronounced both before at clinical onset IDDM. autoantibodies show highest predictive value may represent an initiating autoantigen. Autoantibodies numerous cell autoantigens detected secondary response antigen spreading during sustained autoimmune attack role T cells in human yet defined. have positive for further investigations needed clarify ways predict general population.