A postpartum separation induces c-Fos expression in the supramammillary nucleus of lactating rats
作者： Pudcharaporn Kromkhum , Asa Nagai , Masumi Ichikawa , Toru R. Saito , Makoto Yokosuka
DOI: 10.1007/S12522-009-0013-1
关键词:
摘要: Aim Elucidation of the neural mechanism maternal behaviors is a medically and biologically important research task. The rat laboratory animal most extensively analyzed for behaviors. However, that maintains motivation postpartum rats has not yet been elucidated. In this study, we aimed to identify brain regions involved in maintenance by detecting exhibit changes nerve activity when mother separated from her pups. Methods Lactating were their pups on day 3 kept away certain period time, exhibited those are returned detected immunohistochemistry using anti-c-Fos antibody, marker increased activity. Results Rats with later showed increases number c-Fos immunoreactive (c-Fos-IR) cells medial preoptic area (MPA), bed nucleus stria terminalis (BST), caudal portion posterior hypothalamic (PH) supramamillary (SUM). permanently pups, only PH SUM an increase c-Fos-IR cells. Conclusion rats, aversive memory anxiety level. observed suggests change SUM, which anxiety,
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H. Cohen, I. Sabbagh, P. Guillaumot, J. Bertrand, Increased dopaminergic inhibition of prolactin in the hypoprolactinaemic IPL nude rat. Journal of Endocrinology. ,vol. 107, pp. 325- 329 ,(1985) , 10.1677/JOE.0.1070325
Susana R Valdez, Alicia B Penissi, Ricardo P Deis, Graciela A Jahn, None, Hormonal profile and reproductive performance in lactation deficient (OFA hr/hr) and normal (Sprague-Dawley) female rats. Reproduction. ,vol. 133, pp. 827- 840 ,(2007) , 10.1530/REP-06-0032
MAKOTO YOKOSUKA, SHUNSUKE TAKAGI, MASAHIRO KATOU, KROMKHUM PUDCHARAPORN, SVEINBJORN GIZURARSON, MASUMI ICHIKAWA, TORU R. SAITO, p-Chloroamphetamine-induced rat ejaculation is not associated with the preoptic nucleus or medial nucleus amygdala. Reproductive Medicine and Biology. ,vol. 7, pp. 37- 43 ,(2008) , 10.1111/J.1447-0578.2007.00199.X
Michael Numan, Marilyn J. Numan, Preoptic-brainstem connections and maternal behavior in rats. Behavioral Neuroscience. ,vol. 105, pp. 1013- 1029 ,(1991) , 10.1037/0735-7044.105.6.1013
Jean-Rémi Pape, Gérard Tramu, Suckling-Induced Changes in Neuropeptide Y and Proopiomelanocortin Gene Expression in the Arcuate Nucleus of the Rat: Evaluation of a Putative Intervention of Prolactin Neuroendocrinology. ,vol. 63, pp. 540- 549 ,(1996) , 10.1159/000127083
C SMITH, J LONSTEIN, Contact with infants modulates anxiety-generated c-fos activity in the brains of postpartum rats Behavioural Brain Research. ,vol. 190, pp. 193- 200 ,(2008) , 10.1016/J.BBR.2008.02.030
Jacques Balthazart, Gregory F. Ball, Topography in the preoptic region: differential regulation of appetitive and consummatory male sexual behaviors. Frontiers in Neuroendocrinology. ,vol. 28, pp. 161- 178 ,(2007) , 10.1016/J.YFRNE.2007.05.003
Michael Numan, Marilyn Numan, A lesion and neuroanatomical tract‐tracing analysis of the role of the bed nucleus of the stria terminalis in retrieval behavior and other aspects of maternal responsiveness in rats Developmental Psychobiology. ,vol. 29, pp. 23- 51 ,(1996) , 10.1002/(SICI)1098-2302(199601)29:1<23::AID-DEV2>3.0.CO;2-O
J.M. Blanco, D.E. Wildt, U. Höfle, W. Voelker, A.M. Donoghue, Implementing artificial insemination as an effective tool for ex situ conservation of endangered avian species. Theriogenology. ,vol. 71, pp. 200- 213 ,(2009) , 10.1016/J.THERIOGENOLOGY.2008.09.019
Marilyn J. Numan, Michael Numan, Importance of pup-related sensory inputs and maternal performance for the expression of Fos-like immunoreactivity in the preoptic area and ventral bed nucleus of the stria terminalis of postpartum rats. Behavioral Neuroscience. ,vol. 109, pp. 135- 149 ,(1995) , 10.1037//0735-7044.109.1.135