Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy
作者： Perry B. Hackett , David A. Largaespada , Kirsten C. Switzer , Laurence J.N. Cooper
DOI: 10.1016/J.TRSL.2012.12.005
关键词:
摘要: Investigational therapy can be successfully undertaken using viral- and nonviral-mediated ex vivo gene transfer. Indeed, recent clinical trials have established the potential for genetically modified T cells to improve restore health. Recently, Sleeping Beauty (SB) transposon/transposase system has been applied in stably insert a chimeric antigen receptor (CAR) redirect T-cell specificity. We discuss context which SB harnessed describe human application of SB-modified CAR + cells. focused on theoretical issues relating insertional mutagenesis genomes that are naturally subjected remobilization transposons experimental evidence over last decade employing defining genes induce cancer. These findings put into use treatment disease.
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