Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression.

摘要: Members of the TRP superfamily cation channels have homeostatic and regulatory functions in cells changes their expression may contribute to malignant growth. Previously, we demonstrated that gene Ca2+-selective channel CaT-L or TRPV6 is not expressed benign prostate tissues including hyperplasia, but upregulated cancer. Here, report on differential mRNA tissue obtained from 140 patients with Using situ hybridization, transcripts were undetectable tissue, high-grade prostatic intraepithelial neoplasia (n=57), incidental adenocarcinoma all tumors less than 2.3 cubic centimeter (cc). In prostatectomy specimens 97 clinically organ-confined tumors, correlated significantly Gleason score (P=0.032), pathological stage (P<0.001) extraprostatic extension (P=0.025). Lymph node metastasis (n=17) androgen-insensitive (n=27) revealed 63 67% cases, respectively. The latter, however, markedly decreased levels when compared untreated (P=0.044). summary, data demonstrate associated cancer progression. Accordingly, represents a prognostic marker and, as plasma membrane Ca2+ channel, promising target for new therapeutic strategies treat advanced