Trophoblast Transferrin and Transferrin Receptors in the Host-Parasite Relationship of Human Pregnancy

摘要: Transferrin and specific transferrin receptors are demonstrated on the microvillous surface of syncytiotrophoblast in human immature term placentae by immunohistological techniques with use light electron microscopy. That distribution is limited to materno-foetal interface supports hypothesis that binding maternal trophoblast involved process iron transport foetus. Parallel studies baboon demonstrate presence which bind both transferrin, thereby putting forward an experimental model might be used test biological significance placental primates. In addition, investigation a large number cell lines shows many transformed cells, but no normal cells (such as blood lymphocytes) or from primary culture neonatal foreskin fibroblasts), possess ability their membranes. These findings suggest may play important roles addition mother One such role could limitation intervillous spaces, thus depriving iron-requiring microorganisms iron, hence serving non-specific factor resistance for placentae. Another foetal trophoblasts at interface, frustrating immunosurveillance. This similar mechahism schistosomes host-parasite relation where host proteins bound parasite escape immunological recognition. The suggests this mechanism also employed tumour cells. Finally, view previous show required stimulated lymphocytes pass G$_{1}$ S phase cellular replication, it proposed limit amount spaces impede proliferation possible cytotoxicity activated interface.