The value of serial measurement of both human chorionic gonadotropin and alpha-fetoprotein for monitoring germinal cell tumors

摘要: Quantitative serial serum measurements of human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) levels using sensitive double-antibody radioimmunoassays were performed in nine patients with germinal cell tumors before during treatment. The sera eight the found to have a hCG marker five an AFP marker. four both. Serial hCG, AFP, or both useful for monitoring disease activity therapy all patients. In two tumor masses failed diminish chemotherapy, but markers fell appropriately. At surgery one patient had mature teratoma, other teratoma microscopic focus embryonal tumor. reactivation was reflected by emergence only previosly elevated markers. One rise another coincident recurrence are following response tumors, can assist making therapeutic decisions.