The macrophage in acute neural injury: changes in cell numbers over time and levels of cytokine production in mammalian central and peripheral nervous systems
作者： R.B. Borgens , J.J. Turek , I.A. Schoenlein , L.J. Moriarty , A. Leskovar
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摘要: We evaluated the timing and density of ED-1-positive macrophage accumulation (ED 1 is primary antibody for macrophage) measured cytokine production by macrophages in standardized compression injuries to spinal cord sciatic nerves individual rats 3, 5, 10 21 days post-injury. The actual site mechanical damage nervous tissue, a more distant where Wallerian degeneration had occurred, were both peripheral system (PNS) central (CNS) at these time points. initial activated was similar sites damage. Subsequently, densities all locations studied statistically significantly higher than nerve every point but one. peak concentrations three cytokines, tumor necrosis factor α (TNF α), interleukin-1 (IL-1) interleukin-6 (IL-6), appeared earlier injured nerve. discuss meaning data relative known differences reparative responses PNS CNS injury.
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