Immunology of Hodgkin's disease.

作者: Sibrand Poppema

DOI: 10.1016/S0950-3536(96)80020-5

关键词:

摘要: Hodgkin's disease is characterized by an immune response in the involved tissues that predominantly CD4 mediated. The CD4+ T-cells are CD45RO+ and CD45RBdim, they express several activation markers but lack CD26, vitro can be stimulated to produce gamma-interferon IL-4, not IL-2. This usual immunophenotype cytokine production pattern of Th1, Th2 or Th0 cells may a reflection anergy. cause such anergic reaction clear since RS HLA class II as well co-stimulator molecules CD80 CD86. It possible (hypothetical) super antigen expressed on play role. absence IL-2 however explains CD8 mediated response. In addition that, generally do I, which allows them escape responses. link between ineffective tissue generalized deficiency consist components. These include influx mature into affected tissues, secretion inhibitory neoplastic spill-over T-cell general circulation either Hodgkin related also result IL-4 dominated latter possibility hyper-gamma-globulinaemia frequently observed high IgE levels.

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