Immobilization of thrombocytes on PCL nanofibres enhances chondrocyte proliferation in vitro.
作者： R. Jakubova , A. Mickova , M. Buzgo , M. Rampichova , E. Prosecka
DOI: 10.1111/J.1365-2184.2011.00737.X
关键词:
摘要: Objectives: The aim of this study was to develop functionalized nanofibres as a simple delivery system for growth factors (GFs) and make nanofibre cellseeded scaffold implants one-step intervention. Materials methods: We have polycaprolactone (PCL) with thrombocytes adherent on them. Immobilized, these attached scaffolds were used nanoscale native (autologous) proliferation differentiation factors, in vitro. Pig chondrocytes seeded the thrombocytecoated levels cells compared those non-coated scaffolds. Results: Immobilized PCL effectively enhanced chondrocyte due time-dependent degradation release their GFs. Conclusions: These simply present new possibilities applications, smart cell equipped GF tool.
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