Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma.
作者： Anne Dejean , Lydie Bougueleret , Karl-Heinz Grzeschik , Pierre Tiollais
DOI: 10.1038/322070A0
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摘要: Hepatitis B virus (HBV) is clearly involved in the aetiology of human hepatocellular carcinoma (HCC)1 and finding HBV DNA integration into liver almost all HCCs studied2–7 suggested that these integrated viral sequences may be oncogenesis. Several integrations different HCCs8,9 HCC-derived cell lines10–14 have been analysed after molecular cloning without revealing any obvious role for HBV. From a comparison site present particular HCC8 with corresponding unoccupied non-tumorous tissue same liver, we now report places sequence next to which bears striking resemblance both an oncogene (v-erb-A) supposed DNA-binding domain glucocorticoid receptor oestrogen genes. We suggest this gene, usually silent or transcribed at very low level normal hepatocytes, becomes inappropriately expressed as consequence integration, thus contributing transformation.
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N.K. Spurr, E. Solomon, M. Jansson, D. Sheer, P.N. Goodfellow, W.F. Bodmer, B. Vennstrom, Chromosomal localisation of the human homologues to the oncogenes erbA and B. The EMBO Journal. ,vol. 3, pp. 159- 163 ,(1984) , 10.1002/J.1460-2075.1984.TB01777.X
Medline A, Wanless Ir, Role of estrogens as promoters of hepatic neoplasia. Laboratory Investigation. ,vol. 46, pp. 313- ,(1982)
Jay H. Hoofnagle, Jules Dienstag, Girish N. Vyas, Viral Hepatitis and Liver Disease ,(1985)
Y Shaul, M Ziemer, P D Garcia, R Crawford, H Hsu, P Valenzuela, W J Rutter, Cloning and analysis of integrated hepatitis virus sequences from a human hepatoma cell line. Journal of Virology. ,vol. 51, pp. 776- 787 ,(1984) , 10.1128/JVI.51.3.776-787.1984
Stephen M. Mount, A catalogue of splice junction sequences Nucleic Acids Research. ,vol. 10, pp. 459- 472 ,(1982) , 10.1093/NAR/10.2.459
Stephen Green, Philippe Walter, Vijay Kumar, Andrée Krust, Jean-Marc Bornert, Patrick Argos, Pierre Chambon, Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A Nature. ,vol. 320, pp. 134- 139 ,(1986) , 10.1038/320134A0
B Debuire, C Henry, M Bernissa, G Biserte, J. Claverie, S Saule, P Martin, D Stehelin, Sequencing the erbA gene of avian erythroblastosis virus reveals a new type of oncogene Science. ,vol. 224, pp. 1456- 1459 ,(1984) , 10.1126/SCIENCE.6328658
Jeffrey C. Edman, Patrick Gray, Pablo Valenzuela, Leslie B. Rall, William J. Rutter, Integration of hepatitis B virus sequences and their expression in a human hepatoma cell Nature. ,vol. 286, pp. 535- 538 ,(1980) , 10.1038/286535A0
Cary Weinberger, Stanley M. Hollenberg, Michael G. Rosenfeld, Ronald M. Evans, Domain structure of human glucocorticoid receptor and its relationship to the v- erb-A oncogene product Nature. ,vol. 318, pp. 670- 672 ,(1985) , 10.1038/318670A0
Stanley M. Hollenberg, Cary Weinberger, Estelita S. Ong, Gail Cerelli, Anthony Oro, Roger Lebo, E. Brad Thompson, Michael G. Rosenfeld, Ronald M. Evans, Primary structure and expression of a functional human glucocorticoid receptor cDNA Nature. ,vol. 318, pp. 635- 641 ,(1985) , 10.1038/318635A0