Correlations between intrinsic chemoresistance and HER-2/neu gene expression, p53 gene mutations, and cell proliferation characteristics in non-small cell lung cancer cell lines.

摘要: Using a panel of 20 non-small cell lung cancer (NSCLC) lines established from previously untreated patients, we investigated the relationships between intrinsic chemoresistance (to four agents used commonly in therapy NSCLC) and HER-2/neu gene expression (which encodes glycoprotein p185neu), p53 mutations, proliferation characteristics. Our results demonstrated that high p185neu was correlated with chemoresistance, low S-phase fractions, long doubling times. By contrast, expressing relatively levels were chemosensitive had higher fractions shorter Although mutation common event this (present 18 lines), there no relationship mutations at any specific codon or Multivariate analysis revealed level only independent predictor for to doxorubicin, etoposide, probably cisplatin. almost certainly is multifactorial process, overexpression may be an important factor NSCLC.