The p53 Tumor Suppressor Gene in Lung Cancer: From Molecular to Serological Diagnosis
作者： Thierry Soussi , Jean Tredaniel , Richard Lubin , Gerard Zalcman , Albert Hirsh
DOI: 10.1007/978-3-0348-8924-7_19
关键词: Serology 、 Lung 、 Lung cancer 、 Medicine 、 Carcinogenesis 、 Carcinogen 、 Immunology 、 Cancer research 、 Missense mutation 、 Breast Cancer Prognostic Factor 、 Immunohistochemistry
摘要: Alteration of p53 is the most common alteration found in human cancer. It usually involves missense mutations that frequently stabilize protein, which turn accumulates to reach levels detectable by immunohistochemistry. Analysis mutational events leads significant conclusions concerning mutation and exposure carcinogens. Although does not seem correlate with any clinical parameters, observation such occur very early lung tumorigenesis suggests they can be used for diagnosis.
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