Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients
作者： Eriko Tokunaga , Yasue Kimura , Eiji Oki , Naoyuki Ueda , Motonori Futatsugi
DOI: 10.1002/IJC.21358
关键词:
摘要: … Akt is activated by a variety of stimuli, through growth factor receptors, in a PI-3 kinase–dependent manner. The mechanisms by which Akt … Phosphorylation of Akt is associated with …
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Olle Stål, Gizeh Pérez-Tenorio, Linda Åkerberg, Birgit Olsson, Bo Nordenskjöld, Lambert Skoog, Lars Erik Rutqvist, Akt kinases in breast cancer and the results of adjuvant therapy Breast Cancer Research. ,vol. 5, pp. 1- 8 ,(2003) , 10.1186/BCR569
Carlos L. Arteaga, Hirokazu Kurokawa, Inhibition of erbB receptor (HER) tyrosine kinases as a strategy to abrogate antiestrogen resistance in human breast cancer. Clinical Cancer Research. ,vol. 7, pp. 4436- 4442 ,(2001)
J. Hanson, B. E. Krause, W. A. McBlain, K. D. Dietrich, N. Jamil, J. Danyluk, H. Jenkins, A. H. G. Paterson, A. W. Lees, M. C. Paterson, R. M. Fourney, D. J. Slamon, Correlation between c-erbB-2 amplification and risk of recurrent disease in node-negative breast cancer. Cancer Research. ,vol. 51, pp. 556- 567 ,(1991)
Carlos L. Arteaga, Hirokazu Kurokawa, ErbB (HER) Receptors Can Abrogate Antiestrogen Action in Human Breast Cancer by Multiple Signaling Mechanisms Clinical Cancer Research. ,vol. 9, ,(2003)
Amanda H. McCann, Peter A. Dervan, Desmond N. Carney, Brendan M. J. Tobin, Myra O'Regan, Mary B. Codd, William J. Gullick, Prognostic significance of c-erbB-2 and estrogen receptor status in human breast cancer. Cancer Research. ,vol. 51, pp. 3296- 3303 ,(1991)
, Masaru Izuo, The general rules for clinical and pathological recording of breast cancer Surgery Today. ,vol. 19, pp. 612- 632 ,(1989) , 10.1007/BF02471672
WJ Gullick, SB Love, C Wright, DM Barnes, B Gusterson, AL Harris, DG Altman, c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes British Journal of Cancer. ,vol. 63, pp. 434- 438 ,(1991) , 10.1038/BJC.1991.100
Moulay A Alaoui-Jamali, Jesse Paterson, Ala-Eddin Al Moustafa, Lily Yen, The role of ErbB-2 tyrosine kinase receptor in cellular intrinsic chemoresistance: mechanisms and implications. Biochemistry and Cell Biology. ,vol. 75, pp. 315- 325 ,(1997) , 10.1139/O97-060
Shakeel Ahmad, Nadia Singh, Robert I. Glazer, Role of AKT1 in 17β-estradiol- and insulin-like growth factor I (IGF-I)-dependent proliferation and prevention of apoptosis in MCF-7 breast carcinoma cells Biochemical Pharmacology. ,vol. 58, pp. 425- 430 ,(1999) , 10.1016/S0006-2952(99)00125-2
Xiaojiang Cui, Ping Zhang, Wanleng Deng, Steffi Oesterreich, Yiling Lu, Gordon B. Mills, Adrian V. Lee, Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in breast cancer. Molecular Endocrinology. ,vol. 17, pp. 575- 588 ,(2003) , 10.1210/ME.2002-0318