Suppressor mechanisms in tumor immunity.
作者： G. T. Nepom , I. Hellström , K. E. Hellström
DOI: 10.1007/BF01955286
关键词:
摘要: There are many parallels between T cell-mediated suppression of tumor immunity and immune responses to haptens polypeptides. We propose a cell interaction model which takes this into account outlines regulatory pathway for antigens. Free antigen or antigen/antibody complexes trigger an inducer subset, Tsi, is tumor-specific. This activates non-immune population, pre Ts3, generate effector suppressor cells, Tse. The Tse specific either the idiotype Tsi complexed with soluble factor made by but they mediate antigenically nonspecific. Tumor antigen-specific factors, TsF, play major role in communication different cells. Characterization polyclonal monoclonal factors produced called TsFi, indicates that both bind contain tumor-specific (idiotypic?) determinants.
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